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Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis

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  • Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis
    • 02 JUN 15
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    Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis

    Background. The effectiveness of platelet-rich plasma (PRP) injections for osteoarthritis (OA) is still controversial. We investigated the effect of PRP injections in patients with knee OA based on decreasing pain, improving function, global assessment and changes regarding joint imaging.

    Methods. We performed a comprehensive, systematic literature search in computerised databases (MEDLINE, EMBASE, CINAHL, CENTRAL, Web of Science and PEDro) until June 2014 for randomised or non-randomised controlled trials. These were graded for risk of bias and a level of evidence was provided. If possible, meta-analysis was performed.

    Results. Ten trials were included. In these, intra-articular PRP injections were more effective for pain reduction (mean difference (MD) −2.45; 95% CI −2.92 to −1.98; p value <0.00001 and MD −2.07; 95% CI −2.59 to −1.55; p value <0.00001, single and double PRP injections, respectively) compared with placebo at 6 months postinjection. Intra-articular PRP injections were compared with hyaluronic acid and showed a statistically significant difference in favour of PRP on pain reduction based on the visual analogue scale and numeric rating scale (standardised mean difference −0.92; 95% CI −1.20 to −0.63; p value <0.00001) at 6 months postinjection. Almost all trials revealed a high risk of bias.

    Conclusions. On the basis of the current evidence, PRP injections reduced pain more effectively than did placebo injections in OA of the knee (level of evidence: limited due to a high risk of bias). This significant effect on pain was also seen when PRP injections were compared with hyaluronic acid injections (level of evidence: moderate due to a generally high risk of bias). Additionally, function improved significantly more when PRP injections were compared with controls (limited to moderate evidence). More large randomised studies of good quality and low risk of bias are needed to test whether PRP injections should be a routine part of management of patients with OA of the knee.

    http://bjsm.bmj.com/content/49/10/657.long

    British Journal of Sports Medicine.

    Noviembre 2014

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More from my site

  • The use of autologous platelet-rich plasma in the orthopedic settingThe use of autologous platelet-rich plasma in the orthopedic setting
  • Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial)Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial)
  • The Addition of Platelet-Rich Plasma to Scaffolds Used for Cartilage Repair: A Review of Human and Animal StudiesThe Addition of Platelet-Rich Plasma to Scaffolds Used for Cartilage Repair: A Review of Human and Animal Studies
  • Single injection of platelet-rich plasma (PRP) for the treatment of refractory distal biceps tendonitis: long-term results of a prospective multicenter cohort studySingle injection of platelet-rich plasma (PRP) for the treatment of refractory distal biceps tendonitis: long-term results of a prospective multicenter cohort study
  • Platelet-rich plasma for open meniscal repair in young patients: any benefit?Platelet-rich plasma for open meniscal repair in young patients: any benefit?
  • Plasma rico en plaquetas. Plasma rico en factores de crecimiento. Úlceras cutáneas crónicas. Alopecia. Rejuvenecimiento facial.Plasma rico en plaquetas. Plasma rico en factores de crecimiento. Úlceras cutáneas crónicas. Alopecia. Rejuvenecimiento facial.
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